InterPro domain: IPR012506

The members of this family are similar to the hypothetical protein yhhN expressed by E. coli ( P0ADI9 ). Many are annotated as possible transmembrane proteins, and in fact they all have a high proportion of hydrophobic residues. A human member of this family, formerly known as TMEM86B, is a lysoplasmalogenase that catalyzes the hydrolysis of the vinyl ether bond of lysoplasmalogen [ 1 ]. Putative conserved active site residues have been proposed for the YhhN family [ 2 ].

1. Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen. J. Biol. Chem. 286, 24916-30
2. Large-scale determination of previously unsolved protein structures using evolutionary information. Elife 4, e09248