InterPro domain: IPR012446

General Information

  • Identifier IPR012446
  • Description Calcium release-activated calcium channel protein
  • Number of genes 13
  • Gene duplication stats Loading...

Abstract

This entry includes Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 green fluorescent protein (GFP) reporters are co-expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1-related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins [ 1 ].


1. CRAC channel activity in C. elegans is mediated by Orai1 and STIM1 homologues and is essential for ovulation and fertility. J. Physiol. (Lond.) 580, 67-85

Species distribution

Gene table