InterPro domain: IPR012112
General Information
- Identifier IPR012112
- Description DNA repair protein Rev1
- Number of genes 89
- Gene duplication stats Loading...
- Associated GO terms GO:0006281 GO:0016779 GO:0042276 GO:0003684
Abstract
Rev1 is a deoxycytidyl transferase involved in translesion DNA synthesis (TLS) pathway to bypass DNA lesions during replication [ 1 ]. During TLS, Y-family DNA polymerase (Poleta, Polkappa, Poliota and Rev1) incorporates a nucleotide opposite the DNA lesion, and then Polzeta (consitst of Rev3 and Rev7) carries out primer extension. Rev1 is a unique member of the Y polymerase family, since its catalytic activity is limited to DNA-dependent, deoxycytidyl transferase activity [ 2 , 3 , 4 ].
1. Structural insights into the assembly of human translesion polymerase complexes. Protein Cell 3, 864-74
2. Deoxycytidyl transferase activity of yeast REV1 protein. Nature 382, 729-31
3. Mechanisms of dCMP transferase reactions catalyzed by mouse Rev1 protein. J. Biol. Chem. 277, 3040-6
4. Deoxycytidyl transferase activity of the human REV1 protein is closely associated with the conserved polymerase domain. J. Biol. Chem. 276, 15051-8