InterPro domain: IPR012104

Pho85 is a non-essential cyclin-dependent kinase (CDK) involved in the cell cycle [ 1 ]. Pho85 is controlled by 10 cyclins that may be grouped into 2 families according to cyclin box sequence similarity [ 2 ]: the Pho80 family (Pho80, Pcl6, Pcl7, Pcl8, and Pcl10) and the Pcl1,2 family (Pcl1, Pcl2, Pcl5, Pcl9 and ClG1). Except Pcl5, the rest of the Plc1,2 family members show a tightly controlled cell cycle pattern of expression: Pcl9 is produced in late M phase and during early G1, Pcl2 in late M until late G1, and Pcl1 during late G1 [ 3 ].

This entry includes Pcl1, Pcl2 and Pcl9.

1. Redundancy or specificity? The role of the CDK Pho85 in cell cycle control. Int J Biochem Mol Biol 4, 140-9
2. A family of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase. Mol. Cell. Biol. 17, 1212-23