InterPro domain: IPR012066

General Information

  • Identifier IPR012066
  • Description Uroporphyrin-III C-methyltransferase, fungi

Abstract

This entry represents Met1, an uroporphyrinogen-III C-methyltransferase that is involved in the biosynthesis of siroheme and is required for sulfate assimilation and methionine biosynthesis [ 1 , 2 , 3 ].


1. Siroheme biosynthesis in Saccharomyces cerevisiae requires the products of both the MET1 and MET8 genes. FEBS Lett. 401, 20-4
2. The role of Saccharomyces cerevisiae Met1p and Met8p in sirohaem and cobalamin biosynthesis. Biochem. J. 338 ( Pt 3), 701-8
3. Physiological analysis of mutants of Saccharomyces cerevisiae impaired in sulphate assimilation. J. Gen. Microbiol. 138, 2021-8

Species distribution

Gene table