InterPro domain: IPR012020

This entry represents a group of abhydrolase domain-containing proteins, including mammalian ABHD1/2/3/15 and budding yeast Eht1, Eeb1 and YMR210W.

Human ABHD3 is a phospholipase that may play a role in phospholipids remodeling. It may selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position [ 1 ]. Mouse ABHD2 may play a role in smooth muscle cells migration [ 2 ].

Yeast Eht1 and its paralogue, Eeb1, are Acyl-coenzymeA:ethanol O-acyltransferases involved in medium-chain fatty acid ethyl ester biosynthesis during fermentation [ 3 ]. YMR210W does not seem to play an important role in medium-chain fatty acid ethyl ester formation [ 4 ].

This entry also includes bacterial putative esterases, such as yheT from E. coli.

1. Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids. Nat. Chem. Biol. 7, 763-5
2. Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha/beta hydrolase domain containing 2 gene. Biochem. Biophys. Res. Commun. 329, 296-304
3. The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity. J. Biol. Chem. 281, 4446-56