InterPro domain: IPR011947

General Information

  • Identifier IPR011947
  • Description FCP1-like phosphatase, phosphatase domain
  • Number of genes 436
  • Gene duplication stats Loading...
  • Associated GO terms GO:0004721   GO:0005634  

Abstract

This entry represents the phosphatase domain of the human RNA polymerase II subunit A C-terminal domain phosphatase (FCP1, [ 1 ]) and closely related phosphatases from eukaryotes including plants, fungi [ 2 ] and slime mold. This domain is a member of the haloacid dehalogenase (HAD) superfamily by virtue of a conserved set of three catalytic motifs [ 3 ] and a conserved fold as predicted by PSIPRED. The third motif in this family is distinctive (hhhhDDppphW). This domain is classified as a "Class III" HAD, since there is no large "cap" domain found between motifs 1 and 2 or motifs 2 and 3 [ 4 ]. This domain is related to domains found in the human NLI interacting factor-like phosphatases.


1. An encephalitozoon cuniculi ortholog of the RNA polymerase II carboxyl-terminal domain (CTD) serine phosphatase Fcp1. Biochemistry 43, 7111-20
2. Schizosaccharomyces pombe carboxyl-terminal domain (CTD) phosphatase Fcp1: distributive mechanism, minimal CTD substrate, and active site mapping. J. Biol. Chem. 279, 10892-900
3. Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search. J. Mol. Biol. 244, 125-32
4. MDP-1 is a new and distinct member of the haloacid dehalogenase family of aspartate-dependent phosphohydrolases. Biochemistry 40, 12704-11

Species distribution

Gene table

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