InterPro domain: IPR011858

General Information

  • Identifier IPR011858
  • Description His6-like, eukaryotic-type
  • Number of genes 117
  • Gene duplication stats Loading...
  • Associated GO terms GO:0003949   GO:0000105  

Abstract

This enzyme acts in the biosynthesis of histidine and has been characterised in Saccharomyces cerevisiae [ 1 ] and Arabidopsis [ 2 ] where it complements the Escherichia coli HisA gene. In eukaryotes the gene is known as His6. In bacteria, this gene is found in Fibrobacter succinogenes(Bacteroides succinogenes), presumably due to lateral gene transfer from plants in the rumen gut.


1. Paralogous histidine biosynthetic genes: evolutionary analysis of the Saccharomyces cerevisiae HIS6 and HIS7 genes. Gene 197, 9-17
2. Molecular cloning and characterization of the gene encoding N'-[(5'-phosphoribosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide (BBM II) isomerase from Arabidopsis thaliana. Mol. Gen. Genet. 259, 216-23

Species distribution

Gene table