InterPro domain: IPR011798
General Information
- Identifier IPR011798
- Description Adenosine 5'-phosphosulphate reductase
- Number of genes 29
- Gene duplication stats Loading...
- Associated GO terms GO:0004604 GO:0019344
Abstract
This entry describes recently identified adenosine 5'-phosphosulphate (APS) reductases found in sulphate-assimilatory prokaryotes [ 1 ]. They are homologous to phosphoadenosine phosphosulphate (PAPS) reductase in enterobacteria, cyanobacteria, and yeast, and perform the same overall function in activating inorganic sulphate. They also show detectable homology with plant APS reductase. The presence of two conserved C-terminal motifs (CCXXRKXXPL and SXGCXXCT), thought to form an iron-sulphur cluster distinguishes APS reductases from PAPS reductases.
1. The presence of an iron-sulfur cluster in adenosine 5'-phosphosulfate reductase separates organisms utilizing adenosine 5'-phosphosulfate and phosphoadenosine 5'-phosphosulfate for sulfate assimilation. J. Biol. Chem. 277, 21786-91