InterPro domain: IPR011687

This entry includes glioma tumour suppressor candidate region gene 2 protein (GSCR2) from humans and ribosome biogenesis protein Nop53 from budding yeasts. GSCR2 bears similarity to the glioma tumour suppressor candidate region gene 2 protein (p60) [ 1 ]. Nop53 is a nucleolar protein that is involved in biogenesis of the 60S subunit of the ribosome [ 2 ]. It interacts with Nop17 and Nip7 and is required for pre-rRNA processing in Saccharomyces cerevisiae [ 3 ].

1. A transcript map of the chromosome 19q-arm glioma tumor suppressor region. Genomics 64, 44-50
2. Nop53p is a novel nucleolar 60S ribosomal subunit biogenesis protein. Biochem. J. 388, 819-26
3. Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae. FEBS J. 272, 4450-63