InterPro domain: IPR011644

General Information

  • Identifier IPR011644
  • Description Heme NO-binding
  • Number of genes 5
  • Gene duplication stats Loading...
  • Associated GO terms GO:0020037  

Abstract

The HNOB (Haem NO Binding) domain is a predominantly alpha-helical domain and binds heme via a covalent linkage to histidine [ 1 ]. This domain is found in soluble guanylate cyclases, which are nitric oxide-responsive signaling proteins. It is predicted to function as a haem-dependent sensor for gaseous ligands and to transduce diverse downstream signals in both bacteria and animals. In Clostridium botulinum displays femtomolar affinity for nitrous oxide (NO) [ 2 ].


1. Ancient conserved domains shared by animal soluble guanylyl cyclases and bacterial signaling proteins. BMC Genomics 4, 5
2. Femtomolar sensitivity of a NO sensor from Clostridium botulinum. Science 306, 1550-3

Species distribution

Gene table