InterPro domain: IPR011611
General Information
- Identifier IPR011611
- Description Carbohydrate kinase PfkB
- Number of genes 2176
- Gene duplication stats Loading...
Abstract
This domain is found in a variety of carbohydrate and pyrimidine kinases. It is found in phosphomethylpyrimidine kinase ( 2.7.4.7 ), which is part of the thiamine pyrophosphate (TPP) synthesis pathway - TPP being an essential cofactor for many enzymes [ 1 ]. It is also found in 2-keto-3-deoxygluconate kinase, which is a component of the Entner-Doudoroff pathway in hyperthermophilic archaea [ 2 ].
1. Structure of Escherichia coli ribokinase in complex with ribose and dinucleotide determined to 1.8 A resolution: insights into a new family of kinase structures. Structure 6, 183-93
2. The semi-phosphorylative Entner-Doudoroff pathway in hyperthermophilic archaea: a re-evaluation. Biochem. J. 390, 529-40
Species distribution
Gene table
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