InterPro domain: IPR011547

This entry represents a conserved domain found in a group of sulphate transporters, known as the SLC26A/SulP family [ 1 , 2 ]. These proteins contain an N-terminal membrane domain and a C-terminal cytoplasmic STAS domain a STAS (sulfate transporter and anti-sigma factor antagonist) domain [ 3 ]. This central domain is usually found next to the STAS domain ( IPR002645 ). Proteins containing this domain include:

• Neurospora crassa sulphate permease II (gene cys-14).
• Yeast sulphate permeases (genes SUL1 and SUL2).
• Rat sulphate anion transporter 1 (SAT-1).
• Mammalian DTDST, a probable sulphate transporter which, in human, is involved in the genetic disease, diastrophic dysplasia (DTD).
• Sulphate transporters 1, 2 and 3 from the legume Stylosanthes hamata.
• Human pendrin (gene PDS), which is involved in a number of hearing loss genetic diseases.
• Human protein DRA (Down-Regulated in Adenoma).
• Soybean early nodulin 70.
• Escherichia coli hypothetical protein ychM.
• Caenorhabditis elegans hypothetical protein F41D9.5.

1. Similarities between a soybean nodulin, Neurospora crassa sulphate permease II and a putative human tumour suppressor. Trends Biochem. Sci. 19, 19
2. Isolation of a cDNA from Saccharomyces cerevisiae that encodes a high affinity sulphate transporter at the plasma membrane. Mol. Gen. Genet. 247, 709-15
3. The STAS domain - a link between anion transporters and antisigma-factor antagonists. Curr. Biol. 10, R53-5