InterPro domain: IPR011513
General Information
- Identifier IPR011513
- Description Non-structural maintenance of chromosomes element 1
- Number of genes 140
- Gene duplication stats Loading...
- Associated GO terms GO:0006281 GO:0030915
Abstract
Saccharomyces cerevisiae Nse1 ( Q07913 ) forms part of a complex with SMC5-SMC6. This non-structural maintenance of chromosomes (SMC) complex plays an essential role in genomic stability, being involved in DNA repair and DNA metabolism [ 1 , 2 ]. It is conserved in eukaryotes from yeast to human. Nse1 acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. It also functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks [ 3 , 3 ].
1. Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex. J. Biol. Chem. 278, 45460-7
2. Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J. Biol. Chem. 277, 21585-91