InterPro domain: IPR011421

Vertebrate BCNT (named after Bucentaur) protein is found in the nucleus andcytosol. Gene duplication of the ancestral BCNT gene leads to the h-type BCNTor craniofacial development protein 1 (CFDP1) gene and the ruminant-specificp97BCNT or craniofacial development protein 2 (CFDP2) gene. The h-type BCNTproteins contain a highly conserved 82-amino acid region at the C terminus(BCNT-C) that is not present in p97BCNT. Instead ruminant p97BCNT contains aregion derived from the endonuclease domain of a retrotransposable elementRTE-1 [ 1 , 2 ].

In addition to h-type BCNT proteins, a BCNT-C domain is alsofound in Drosophila YETI, a protein that binds to a microtubule-based motorkinesin-1, and the yeast SWR1-complex protein 5 (SWC5) or AOR1 (actinoverexpression resistant 1), a component of the SWR1 chromatin remodelingcomplex [ 3 , 3 ].

The entry represents the entire BCNT-C domain.

1. A transposable element-mediated gene divergence that directly produces a novel type bovine Bcnt protein including the endonuclease domain of RTE-1. Mol. Biol. Evol. 20, 1556-63
2. A tandem gene duplication followed by recruitment of a retrotransposon created the paralogous bucentaur gene (bcntp97) in the ancestral ruminant. Mol. Biol. Evol. 23, 798-806
3. The Drosophila kinesin-I associated protein YETI binds both kinesin subunits. Biol. Cell 95, 595-602