InterPro domain: IPR011417

General Information

  • Identifier IPR011417
  • Description AP180 N-terminal homology (ANTH) domain
  • Number of genes 1711
  • Gene duplication stats Loading...
  • Associated GO terms GO:0005543  

Abstract

The AP180 N-terminal homology (ANTH) domain is a membrane binding domain found in endocytotic accessory proteins, such as AP180. AP180 has been implicated in the formation of clathrin-coated pits. The ANTH domain is involved in phosphatidylinositol 4,5-bisphosphate (also known as PIP2) binding. The ANTH domain containing proteins appear to be universal elements in nucleation of clathrin coats [ 1 , 2 ].


1. Contrasting membrane interaction mechanisms of AP180 N-terminal homology (ANTH) and epsin N-terminal homology (ENTH) domains. J. Biol. Chem. 278, 28993-9
2. ENTH/ANTH domains expand to the Golgi. Trends Cell Biol. 13, 211-5

Species distribution

Gene table