InterPro domain: IPR011410
General Information
- Identifier IPR011410
- Description Nucleoside diphosphate kinase 7
- Number of genes 4
- Gene duplication stats Loading...
- Associated GO terms GO:0005524 GO:0004550
Abstract
The nm23-H7 nucleoside diphosphate kinase (also known as NDPk7 or NME7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amounts are also found in liver, heart, brain, ovary, small intestine and spleen [ 1 ]. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner [ 2 , 3 ].
1. The human Nm23/nucleoside diphosphate kinases. J. Bioenerg. Biomembr. 32, 247-58
2. Expression of the nm23 homologues nm23-H4, nm23-H6, and nm23-H7 in human gastric and colon cancer. J. Pathol. 205, 623-32
3. The NM23 family in development. Mol. Cell. Biochem. 329, 17-33