InterPro domain: IPR011388

General Information

  • Identifier IPR011388
  • Description Sphingolipid delta4-desaturase

Abstract

This group represents sphingolipid delta-4 desaturase (DEGS), an integral membrane protein required for sphingosine biosynthesis. It converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) [ 1 ]. Delta4-desaturated sphingolipids provide an early signal that triggers the entry into both meiotic and spermatid differentiation pathways during Drosophila spermatogenesis [ 2 ].


1. Identification and characterization of a sphingolipid delta 4-desaturase family. J. Biol. Chem. 277, 25512-8

Species distribution

Gene table