InterPro domain: IPR011383

SET domain methyltransferases can be involved both in translational and transcriptional roles. N-lysine methyltransferase SETD6 is a SET domain protein that specifically monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity [ 1 ]. Homologues in yeast monomethylate 60S ribosomal protein L42 (RPL42A and RPL42B) at 'Lys-55' [ 2 , 3 ].

1. Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat. Immunol. 12, 29-36
2. A novel SET domain methyltransferase modifies ribosomal protein Rpl23ab in yeast. J. Biol. Chem. 280, 34590-8
3. Methylation of ribosomal protein L42 regulates ribosomal function and stress-adapted cell growth. J. Biol. Chem. 285, 22448-60