InterPro domain: IPR011330
General Information
- Identifier IPR011330
- Description Glycoside hydrolase/deacetylase, beta/alpha-barrel
- Number of genes 571
- Gene duplication stats Loading...
- Associated GO terms GO:0005975 GO:0003824
Abstract
This superfamily represents a structural domain found in glycoside hydrolase families 38 ( GH38 , e.g. alpha-mannosidase) [ 1 ] and 57 ( GH57 , e.g. 4-alpha-glucanotransferase, N-terminal) [ 2 ], as well as in NodB-like polysaccharide deacetylase and in some hypothetical proteins (e.g. TT1467, N-terminal domain). This domain consists of a 7-stranded beta/alpha barrel, although in some families the beta-barrels may be distorted and may vary in the number of strands.
1. Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates. J. Biol. Chem. 278, 48074-83
2. Crystal structures of 4-alpha-glucanotransferase from Thermococcus litoralis and its complex with an inhibitor. J. Biol. Chem. 278, 19378-86