InterPro domain: IPR011256

The effector domain is found in bacterial regulatory proteins, such as transcription factors. The effector domain consists of a duplication of a beta/alpha/beta(2) motif, where the antiparallel beta sheets form a barrel structure. Several proteins contain this domain, such as the multidrug-binding domain of the transcription factor BmrR, which transcriptionally regulates multidrug transporters as well as acting as a multidrug-binding protein [ 1 ], the C-terminal domain of the Rob transcription factor, which belongs to the AraC/XylS protein family that regulate genes involved in resistace to antibiotics, organic solvents and heavy metals [ 2 ], and the gyrase inhibitory protein GyrI (SbmC, TeeB), which is induced by DNA damaging agents to suppress cell proliferation by inhibiting bacterial gyrase activity [ 3 ].

1. Structural mechanisms of multidrug recognition and regulation by bacterial multidrug transcription factors. Mol. Microbiol. 45, 885-93
2. Crystal structure of the Escherichia coli Rob transcription factor in complex with DNA. Nat. Struct. Biol. 7, 424-30
3. Crystal structure of the Escherichia coli SbmC protein that protects cells from the DNA replication inhibitor microcin B17. Proteins 47, 403-7