InterPro domain: IPR011127
General Information
- Identifier IPR011127
- Description D-alanine--D-alanine ligase, N-terminal domain
- Number of genes 125
- Gene duplication stats Loading...
Abstract
This entry represents the N-terminal region of the D-alanine--D-alanine ligase enzyme ( 6.3.2.4 ) which is thought to be involved in substrate binding [ 1 ]. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF) [ 2 ].
1. The molecular basis of vancomycin resistance in clinically relevant Enterococci: crystal structure of D-alanyl-D-lactate ligase (VanA). Proc. Natl. Acad. Sci. U.S.A. 97, 8921-5
2. D-alanine:D-alanine ligase: phosphonate and phosphinate intermediates with wild type and the Y216F mutant. Biochemistry 36, 2531-8