InterPro domain: IPR011108
General Information
- Identifier IPR011108
- Description Zn-dependent metallo-hydrolase, RNA specificity domain
- Number of genes 512
- Gene duplication stats Loading...
Abstract
The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in IPR001279 and are common to all metallo-beta-lactamases. This, the fifth motif [ 1 ], appears to be specific to Zn-dependent metallohydrolases such as ribonuclease J 2 [ 2 ] which are involved in the processing of mRNA [ 3 , 4 ]. This domain adds essential structural elements to the CASP-domain and is unique to RNA/DNA-processing nucleases, showing that they are pre-mRNA 3'-end-processing endonucleases [ 5 , 5 , 5 ].
1. Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family. Nucleic Acids Res. 30, 3592-601
2. Characterization of components of the Staphylococcus aureus mRNA degradosome holoenzyme-like complex. J. Bacteriol. 193, 5520-6
3. Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. Nature 444, 953-6
4. Crystal structure of an archaeal cleavage and polyadenylation specificity factor subunit from Pyrococcus horikoshii. Proteins 78, 2395-8