InterPro domain: IPR011054

The rudiment single hybrid motif has a beta-barrel sandwich hybrid motif, consisting of a sandwich of half-barrel shaped beta-sheets. This motif is found in the small domain of cytochrome f [ 1 ], as well as in the C-terminal domain of the biotin carboxylase subunit of acetyl-CoA carboxylase [ 2 ], and its family members, such as glycinamide ribonucleotide synthetase C-terminal domain [ 3 ], N5-carboxyaminoimidazole ribonucleotide synthetase PurK C-terminal domain [ 4 ], and glycinamide ribonucleotide transformylase PurT C-terminal domain [ 5 ].

1. Structure of the soluble domain of cytochrome f from the cyanobacterium Phormidium laminosum. Biochemistry 38, 9590-9
2. Movement of the biotin carboxylase B-domain as a result of ATP binding. J. Biol. Chem. 275, 16183-90
3. X-ray crystal structure of glycinamide ribonucleotide synthetase from Escherichia coli. Biochemistry 37, 15647-62
4. Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily. Biochemistry 38, 15480-92
5. PurT-encoded glycinamide ribonucleotide transformylase. Accommodation of adenosine nucleotide analogs within the active site. J. Biol. Chem. 277, 23898-908