InterPro domain: IPR011039
General Information
- Identifier IPR011039
- Description Transcription Factor IIF, Rap30/Rap74, interaction
- Number of genes 390
- Gene duplication stats Loading...
- Associated GO terms GO:0006367
Abstract
Transcription factor IIF (TFIIF), which is essential for eukaryotic transcription by RNA polymerase II. (PolII), consists of a heterodimer of Rap30 (beta) ( IPR003196 ) and Rap74 (alpha) ( IPR008851 ) subunits [ 1 ]. Rap30 and Rap74 have multiple domains that bind to PolII, TFIIB, TAF250 and DNA in interactions that are essential for transcription initiation and elongation. The N-terminal interactions domains of Rap30 and Rap74 are responsible for establishing the dimer interface between the two subunits, this interface being important for TFIIF function [ 2 ].
1. Novel dimerization fold of RAP30/RAP74 in human TFIIF at 1.7 A resolution. J. Mol. Biol. 302, 1119-27
2. A key role for the alpha 1 helix of human RAP74 in the initiation and elongation of RNA chains. J. Biol. Chem. 277, 46998-7003