InterPro domain: IPR010844

This represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localises to tight junctions [ 1 ], while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA [ 2 ]. This shared domain is thought to mediate protein interactions [ 3 ].

1. Occludin: a novel integral membrane protein localizing at tight junctions. J. Cell Biol. 123, 1777-88
2. An RNA polymerase II elongation factor encoded by the human ELL gene. Science 271, 1873-6