InterPro domain: IPR010730

This entry represents a conserved region approximately 150 residues long within various heterokaryon incompatibility proteins that seem to be restricted to ascomycete fungi. Genetic differences in specific het genes prevent a viable heterokaryotic fungal cell from being formed by the fusion of filaments from two different wild-type strains [ 1 ]. Many proteins of this entry also contain the WD domain, G-beta IPR001680 repeat and the NACHT IPR007111 domain.

1. HET-E and HET-D belong to a new subfamily of WD40 proteins involved in vegetative incompatibility specificity in the fungus Podospora anserina. Genetics 161, 71-81