InterPro domain: IPR010652

General Information

  • Identifier IPR010652
  • Description Domain of unknown function DUF1232
  • Number of genes 121
  • Gene duplication stats Loading...

Abstract

This domain can be found in RNF170 from eukaryotes and some uncharacterised proteins from bacteria and archaea. RNF170 is an E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway [ 1 ].


1. RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation. J. Biol. Chem. 286, 24426-33

Species distribution

Gene table