InterPro domain: IPR010643
General Information
- Identifier IPR010643
- Description Helical and beta-bridge domain
- Number of genes 119
- Gene duplication stats Loading...
Abstract
HBB is the domain on DEAD-box eukaryotic DNA repair helicases ([intenz:3.6.1.-]) that appears to be a unique fold. It's conformation is of alpha-helices 12-16 plus a short beta-bridge to the FeS-cluster domain at the N-terminal. The full-length XPD protein verifies the presence of damage to DNA and allows DNA repair to proceed. XPD is an assembly of several domains to form a doughnut-shaped molecule that is able to separate two DNA strands and scan the DNA for damage. HBB helps to form the overall DNA-clamping architecture [ 1 ]. This family represents a conserved region within a number of eukaryotic DNA repair helicases ([intenz:3.6.1.-]).
1. Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD. PLoS Biol. 6, e149