InterPro domain: IPR010488

This entry represents a domain originally identified in bacterial zeta toxin proteins, where it comprises the whole protein [ 1 ]. It has subsequently been found in a number of other proteins, such as polynucleotide kinase and 2',3'-cyclic-nucleotide 3'-phosphodiesterase. It appears to function as a kinase domain [ 2 , 3 ].

1. Crystal structure of the plasmid maintenance system epsilon/zeta: functional mechanism of toxin zeta and inactivation by epsilon 2 zeta 2 complex formation. Proc. Natl. Acad. Sci. U.S.A. 100, 1661-6
2. Structure of a tRNA repair enzyme and molecular biology workhorse: T4 polynucleotide kinase. Structure 10, 1249-60
3. A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis. PLoS Biol. 9, e1001033