InterPro domain: IPR010482

This domain can be found in yeast peroxisomal proteins, such as PEX28-32 family members. This domain can also be found in animal TECPR1 family members.

Peroxisomes play diverse roles in the cell, compartmentalising many activities related to lipid metabolism and functioning in the decomposition of toxic hydrogen peroxide. Sequence similarity was identified between two hypothetical proteins and the peroxin integral membrane protein Pex24p [ 1 ].

In humans, TECPR1 is a tethering factor involved in autophagy [ 2 ].

1. YHR150w and YDR479c encode peroxisomal integral membrane proteins involved in the regulation of peroxisome number, size, and distribution in Saccharomyces cerevisiae. J. Cell Biol. 161, 321-32
2. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host Microbe 9, 376-89