InterPro domain: IPR010422

This entry includes coiled-coil domain-containing protein 124 (Ccdc124) from animals and Oxs1 from fission yeasts. Ccdc124 is a centrosome and midbody protein involved in cytokinesis [ 1 ]. Oxs1 (SPBC29A10.12) is part of the Pap1-Oxs1 complex that regulates transcription when cells are exposed to diamide or Cd that causes disulfide stress [ 2 ].

1. Coiled-coil domain containing protein 124 is a novel centrosome and midbody protein that interacts with the Ras-guanine nucleotide exchange factor 1B and is involved in cytokinesis. PLoS ONE 8, e69289
2. A Pap1-Oxs1 signaling pathway for disulfide stress in Schizosaccharomyces pombe. Nucleic Acids Res. 45, 106-114