InterPro domain: IPR010401
General Information
- Identifier IPR010401
- Description Glycogen debranching enzyme
- Number of genes 1
- Gene duplication stats Loading...
- Associated GO terms GO:0005980 GO:0004135 GO:0004134
Abstract
This family includes human glycogen branching enzyme AGL [ 1 ] and yeast Gdb1 [ 2 ]. This enzyme contains a number of distinct catalytic activities. In Saccharomyces cerevisiae, Gdb1 is a multifunctional enzyme that acts as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation [ 3 ].
1. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev. 21, 2399-409
2. The Saccharomyces cerevisiae YPR184w gene encodes the glycogen debranching enzyme. FEMS Microbiol. Lett. 193, 105-10
3. The Saccharomyces cerevisiae fermentation stress response protein Igd1p/Yfr017p regulates glycogen levels by inhibiting the glycogen debranching enzyme. FEMS Yeast Res. 11, 499-508