InterPro domain: IPR010400

This entry represents the PITH domain (derived from Proteasome-Interacting THioredoxin). The protein Txnl1, which is a probable component of the 32kDa 26S proteasome, uses its C-terminal PITH domain to associate specifically with the 26S proteasome [ 1 ].

The PITH domain is dominated by a jelly roll beta-sandwich structure. The beta-sandwich is formed by face-to-face packing of two anti-parallel beta-sheets. Another two-stranded beta-sheet seals off one end of the beta-barrel [ 2 , 3 ].

1. Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome. J. Biol. Chem. 284, 15246-54
2. Solution structure of At3g04780.1-des15, an Arabidopsis thaliana ortholog of the C-terminal domain of human thioredoxin-like protein. Protein Sci. 14, 1059-63
3. Solution structure of the C-terminal DUF1000 domain of the human thioredoxin-like 1 protein. Proteins 78, 2176-80