InterPro domain: IPR010304
General Information
- Identifier IPR010304
- Description Survival motor neuron
- Number of genes 107
- Gene duplication stats Loading...
- Associated GO terms GO:0005634 GO:0003723 GO:0005737 GO:0006397
Abstract
This family consists of several eukaryotic survival motor neuron (SMN) proteins. The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large macromolecular complex (SMN complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). The SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit, and potentially deleterious, non-specific binding of Sm proteins to RNAs [ 1 ].
1. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. Cell 135, 497-509
Species distribution
Gene table
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