InterPro domain: IPR010300
General Information
- Identifier IPR010300
- Description Cysteine dioxygenase type I
- Number of genes 4
- Gene duplication stats Loading...
- Associated GO terms GO:0016702 GO:0005506
Abstract
Cysteine dioxygenase (CDO) plays an important role in the homeostatic regulation of steady-state cysteine levels and provides important oxidized metabolites of cysteine such as sulfate and taurine. It converts cysteine to cysteinesulphinic acid and is the rate-limiting step in sulphate production [ 1 ].
This entry also includes a cysteine dioxygenase homologue from Pseudomonas aeruginosa known as p3MDO. It functions as a 3-mercaptopropionate dioxygenase that catalyses the dioxygenation of 3-MPA to 3-sulfinopropionic acid (3-SPA) [ 2 ]. 3-Mercaptopropionic acid (3-MPA) is a structural analogue of cysteine.
1. Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria. J. Bacteriol. 188, 5561-9
2. The cysteine dioxygenase homologue from Pseudomonas aeruginosa is a 3-mercaptopropionate dioxygenase. J. Biol. Chem. 290, 24424-37