InterPro domain: IPR010137
General Information
- Identifier IPR010137
- Description Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
- Number of genes 127
- Gene duplication stats Loading...
- Associated GO terms GO:0008780 GO:0008610
Abstract
This entry describes LpxA, an enzyme for the biosynthesis of lipid A, a component of lipopolysaccharide (LPS) in the outer membrane outer leaflet of most Gram-negative bacteria. Some differences are found between lipid A of different species, but this protein represents the first step (from UDP-N-acetyl-D-glucosamine) and appears to be conserved in function [ 1 ]. Proteins from this family contain many copies of the bacterial transferase hexapeptide repeat [ 2 ].
1. Nucleotide substrate recognition by UDP-N-acetylglucosamine acyltransferase (LpxA) in the first step of lipid A biosynthesis. J. Mol. Biol. 369, 305-12
2. Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase. Proc. Natl. Acad. Sci. U.S.A. 104, 13543-50