InterPro domain: IPR010073

This entry represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is known as large PurL and is found mostly in eukaryotes and proteobacteria. In Bacillus subtilis PurL (FGAM synthase II), PurQ (FGAM synthase I) and PurS, of unknown function, perform the equivalent function [ 1 ].

1. The yexA gene product is required for phosphoribosylformylglycinamidine synthetase activity in Bacillus subtilis. Microbiology (Reading, Engl.) 146 ( Pt 4), 807-14