InterPro domain: IPR010036
General Information
- Identifier IPR010036
- Description Magnesium-dependent phosphatase-1, eukaryotic/archaeal-type
- Number of genes 184
- Gene duplication stats Loading...
- Associated GO terms GO:0016791
Abstract
This entry represents two closely related clades of sequences from eukaryotes and archaea, however, some uncharacterised bacterial sequences are also included in this family. The mouse enzyme has been characterised as a phosphatase and has been positively identified as a member of the haloacid dehalogenase (HAD) superfamily by site-directed mutagenesis of the active site residues [ 1 , 2 ]. Its structure is similar to other HAD members but MDP-1 appears to be equally able to dephosphorylate phosphotyrosine and closed-ring phosphosugars [ 3 ].
1. MDP-1 is a new and distinct member of the haloacid dehalogenase family of aspartate-dependent phosphohydrolases. Biochemistry 40, 12704-11
2. MDP-1: A novel eukaryotic magnesium-dependent phosphatase. Biochemistry 39, 8315-24
3. X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily. Biochemistry 43, 12770-9