InterPro domain: IPR010021

This group of proteins is a part of the IIIA subfamily of the haloacid dehalogenase (HAD) superfamily of hydrolases. All characterised members of this subfamily and most characterised members of the HAD superfamily are phosphatases. HAD superfamily phosphatases contain active site residues in several conserved catalytic motifs [ 1 ], all of which are found conserved here.

This family consists of sequences from fungi, plants, cyanobacteria, Gram-positive bacteria and Deinococcus. Proteins in this entry Includes phosphatidylglycerophosphatase Gep4 from budding yeasts and phosphatidylglycerophosphate phosphatase 1 (PGPP1) from plants. Gep4 is involved in the biosynthesis of cardiolipin and phosphatidylethanolamine for survival of prohibitin-deficient cells [ 2 , 3 ]. Chloroplastic PGPP1 is involved in the biosynthesis of phosphatidylglycerol (PG), a phosphoglycerolipid present in chloroplastic thylakoid membranes and has a photosynthetic function [ 4 ].

1. Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search. J. Mol. Biol. 244, 125-32
2. The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J. Cell Biol. 184, 583-96
3. A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4. EMBO J. 29, 1976-87
4. Isolation and characterization of a phosphatidylglycerophosphate phosphatase1, PGPP1, in Chlamydomonas reinhardtii. Plant Physiol. Biochem. 92, 56-61