InterPro domain: IPR010014
General Information
- Identifier IPR010014
- Description Diphthamide synthesis DHP2
- Number of genes 136
- Gene duplication stats Loading...
- Associated GO terms GO:0017183
Abstract
DPH2, also known as diphthamide biosynthesis protein 2 or 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2, has been shown in Saccharomyces cerevisiae (Baker's yeast) to be one of several required for the modification of a particular histidine residue of translation elongation factor 2 to diphthamide [ 1 ]. This modified site can then become the target for ADP-ribosylation by diphtheria toxin [ 2 ]. DPH proteins are highly conserved among eukaryotes [ 3 ].
1. Diphthamide synthesis in Saccharomyces cerevisiae: structure of the DPH2 gene. Gene 132, 149-54
2. Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. Mol. Cell. Biol. 24, 9487-97