InterPro domain: IPR009890

This family contains a number of eukaryotic etoposide-induced 2.4 (ei24) proteins. In cells treated with the cytotoxic drug etoposide, ei24 is induced by p53 and may play an important role in negative cell growth control by functioning as an apoptotic effector of p53 tumor suppressor activities [ 1 ]. These proteins regulate the formation of degradative autolysosomes during autophagy [ 2 , 3 ].

1. Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells. Oncogene 12, 1181-7
2. Apoptosis factor EI24/PIG8 is a novel endoplasmic reticulum-localized Bcl-2-binding protein which is associated with suppression of breast cancer invasiveness. Cancer Res. 65, 2125-9
3. C. elegans screen identifies autophagy genes specific to multicellular organisms. Cell 141, 1042-55