InterPro domain: IPR009846

This family consists of several eukaryotic splicing factor 3B subunit 5 (SF3b5) proteins. SF3b5 is a 10kDa subunit of the splicing factor SF3b. SF3b associates with the splicing factor SF3a and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex. SF3b5 and SF3b14b are also thought to facilitate the interaction of U2 with the branch site [ 1 ]. Also included in this entry is RDS3 complex subunit 10, another protein involved in mRNA splicing [ 2 ].

1. Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. EMBO J. 21, 4978-88
2. Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicing. EMBO J. 23, 4847-56