InterPro domain: IPR009828

General Information

  • Identifier IPR009828
  • Description CYRIA/CYRIB, Rac1 binding domain
  • Number of genes 83
  • Gene duplication stats Loading...
  • Associated GO terms GO:0031267  

Abstract

This domain has been annotated as Rac1-binding domain [ 1 , 2 ]. It can be found in human CYRIA/CYRIB and at the N terminus of CYFIP1/2 [ 3 ]. CYFIP proteins are known RAC1 effectors that stimulate actin polymerization [ 4 ]. In mice, CYRIB (also known as CYRI or FAM49B) negatively regulates RAC1-driven cytoskeletal remodelling and plays a role in restricting infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes [ 4 ].


1. CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors. Commun Integr Biol 12, 112-118
2. Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nat. Cell Biol. 20, 1159-1171
3. CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection. Nat Microbiol 4, 1516-1531

Species distribution

Gene table