InterPro domain: IPR009772

This family contains a number of eukaryotic cell division cycle 123 (Cdc123, also known as D123) proteins approximately 330 residues long. It has been shown that mutated variants of Cdc123 exhibit temperature-dependent differences in their degradation rate [ 1 ]. Budding yeast Cdc123 regulates the cell cycle in a nutrient dependent manner [ 2 ].

1. Reversion of temperature-sensitive mutation by inhibition of proteasome-mediated degradation of mutated D123 protein. Cell Struct. Funct. 26, 205-14
2. Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance. J. Biol. Chem. 279, 44656-66