InterPro domain: IPR009688

This domain is found in mitochondrial proteins, including FAM210A (and its homologues) and B, which contains a transmembrane peptide [ 1 , 2 , 3 ]. Its function is not clear. FAM210A, a protein essential in maintaining skeletal muscle structure and strength [ 4 ], interacts with mitochondrial translation elongation factor EF‐Tu and promotes mitochondrial protein expression. In FAM210A, this domain is responsible for binding EF‐Tu [ 5 ]. FAM210B plays a role in erythroid differentiation and is involved in cell proliferation and tumor cell growth suppression [ 5 , 5 ]. This domain is also present in the uncharacterised protein C106.07c from fission yeast and putative N-terminal acetyltransferase 2 from Baker's yeast.

1. Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming. Cell Death Dis 8, e2870
2. A Multi-Network Comparative Analysis of Transcriptome and Translatome Identifies Novel Hub Genes in Cardiac Remodeling. Front Genet 11, 583124
3. MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling. EMBO Mol Med 13, e12710
4. FAM210A is a novel determinant of bone and muscle structure and strength. Proc Natl Acad Sci U S A 115, E3759-E3768
5. Identification of a novel putative mitochondrial protein FAM210B associated with erythroid differentiation. Int J Hematol 103, 387-95