InterPro domain: IPR009675
General Information
- Identifier IPR009675
- Description TPX2
- Number of genes 830
- Gene duplication stats Loading...
- Associated GO terms GO:0005819 GO:0032147 GO:0060236 GO:0005874
Abstract
This family represents the eukaryotic targeting protein for Xklp2 (TPX2). TPX2 is a microtubule-associated protein that targets a plus end-directed motor (Xklp2) to the minus ends of microtubules in the mitotic spindle. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity [ 1 ]. It is phosphorylated during mitosis in a microtubule-dependent way [ 2 ]. TPX2 activates Aurora A kinase by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation [ 3 ].
1. Xklp2, a novel Xenopus centrosomal kinesin-like protein required for centrosome separation during mitosis. Cell 84, 49-59
2. TPX2, A novel xenopus MAP involved in spindle pole organization. J. Cell Biol. 149, 1405-18
3. Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. J. Cell Biol. 182, 289-300