InterPro domain: IPR009668

General Information

  • Identifier IPR009668
  • Description RNA polymerase I associated factor, A49-like
  • Number of genes 156
  • Gene duplication stats Loading...
  • Associated GO terms GO:0003677   GO:0006351  

Abstract

Saccharomyces cerevisiae A49 is a specific subunit associated with RNA polymerase I (Pol I) in eukaryotes. Pol I maintains transcription activities in A49 deletion mutants. However, such mutants are deficient in transcription activity at low temperatures. Deletion analysis of the fusion yeast homologue indicates that only the C-terminal two thirds are required for function. Transcript analysis has demonstrated that A49 is maximising transcription of ribosomal DNA [ 1 ].


1. The fission yeast RPA51 is a functional homolog of the budding yeast A49 subunit of RNA polymerase I and required for maximizing transcription of ribosomal DNA. Genes Genet. Syst. 78, 199-209

Species distribution

Gene table