InterPro domain: IPR009571

This entry consists of several fungal-specific membrane proteins, including Sur7 and Rim9.

Sur7 carries four transmembrane domains and is a long-lived component of eisosomes, which are large immobile cell cortex structures associated with endocytosis [ 1 ]. It is involved in sporulation [ 2 ].

This entry also includes PalI which is part of a pH signal transduction cascade. Based on the similarity of PalI to the yeast Rim9 meiotic signal transduction component it has been suggested that PalI might be a membrane sensor for ambient pH [ 3 ].

1. Identification of long-lived proteins retained in cells undergoing repeated asymmetric divisions. Proc. Natl. Acad. Sci. U.S.A. 111, 14019-26
2. The Sur7p family defines novel cortical domains in Saccharomyces cerevisiae, affects sphingolipid metabolism, and is involved in sporulation. Mol. Cell. Biol. 22, 927-34
3. Putative membrane components of signal transduction pathways for ambient pH regulation in Aspergillus and meiosis in saccharomyces are homologous. Mol. Microbiol. 30, 259-64