InterPro domain: IPR009543

This entry represents a domain, known as SHR-BD, found in vacuolar protein sorting-associated protein 13 (VPS13). In plants, this domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY ( Q9FT44 ) [ 1 ].

Proteins containing this domain may play a role in the control of protein cycling through the trans-Golgi network. Vacuolar sorting protein is an ATPase required for endosomal trafficking [ 2 ]. Defects in the human protein VPS13A cause chorea-acanthocytosis, an autosomal recessive neurodegenerative disorder characterised by the gradual onset of hyperkinetic movements and abnormal erythrocyte morphology [ 3 ].

1. Reading illustrated science texts: a micro-computer based investigation of children's strategies. Br J Educ Psychol 60 ( Pt 1), 76-87
2. ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking. Mol. Biol. Cell 11, 227-39
3. A conserved sorting-associated protein is mutant in chorea-acanthocytosis. Nat. Genet. 28, 119-20